BIOGRAPHY

Frank J.M.F. Dor was born on April 15th, 1976 in Rotterdam, The Netherlands. From 1988-1994 he attended the Gymnasium Erasmianum in Rotterdam. After graduation, he studied Medicine at the Rijks Universitair Centrum Antwerpen, Belgium. In 1995, he started his medical studies at the Erasmus University Rotterdam (EUR). During the second year of medical school, he became interested in research and started a project at the department of Chemical Pathology (Prof. Dr H.G. van Eijk), leading to his first publications.

Immunology became favorite; following electives at the department of Immunology (Prof. Dr R. Benner), he got involved in a research project on endocrine autoimmune diseases (Prof. Dr H.A. Drexhage).

In 1998, he was offered the opportunity to work in the Royal Free Hospital in London, UK, for some months at the department of Chemical Pathology & Human Metabolism (Prof. Dr. A.F. Winder).

In the same year he became a student research fellow at the departments of Cardio-thoracic Surgery (Prof. Dr A.J.J.C. Bogers) and Transplantation (Prof. Dr W. Weimar) of the University Hospital Rotterdam, where he was involved in research investigating heart valve transplantation in a rat model until 2001.

In 1999, he received a Fujisawa-Grant for a clinical training in (Transplantation) Surgery at the Universitätsklinik Ulm, Germany (Dr M. Storck). Later, in 2000, he visited the Philipps Universitätsklinik Marburg for a clinical training in General and Vascular Surgery (Prof. Dr M. Rothmund / Prof. Dr M. Storck).

He received the Hippocrates Study Prize in 2000 because of "excellent scientific research fulfilled during the medical education”.

After he graduated cum laude from Medical School in November 2001, he started his PhD project in January 2002 at the Transplantation Biology Research Center, Massachusetts General Hospital, Harvard Medical School in Boston, USA (Prof. Dr D.K.C. Cooper / Prof. Dr D.H. Sachs). Here, he performed his experimental work until January 2004 with financial support of the Ter Meulen Fund of the Royal Netherlands Academy of Arts and Sciences (KNAW), the Prof. Michael-van Vloten Fund, and the Netherlands-America Foundation.

During this period, he received a Trainee Award of the Basic Sciences Symposium 2003 of the Transplantation Society, and the Young Investigators Award of the American Transplant Congress 2004 of the American Society of Transplant Surgeons and the American Society of Transplantation. The Royal Netherlands Academy of Arts and Sciences (KNAW) awarded the final scientific report at the end of his Fellowship with the predicate cum laude.

In April 2004, he started his surgical residency at the Department of Surgery of the Erasmus MC Rotterdam (Prof Dr J.N.M. IJzermans / Prof Dr H.J. Bonjer) and continued his training in surgery at the Sint Franciscus Gasthuis Rotterdam (Dr C. Wittens) in April 2006.

In 2005, he was elected as a member of the Editorial Boards of the ASAIO Journal (American Society for Artificial Internal Organs) and the Internet Journal of Surgery.

In the same year, he was appointed as a teacher at the Erasmus MC Educational Institute for ER nurses.

He was appointed as Managing Editor of “Frontiers in Bioscience” in 2006, and is currently editing a special issue of the Journal, entitled “Transplantation: current developments and future directions”.

He is currently a reviewer for the international journals "Xenotransplantation" (since 2003), the "American Journal of Transplantation" (since 2004), "Transplant International" (since 2005), "Artificial Organs" (since 2005), "The Journal of Immunology" (since 2005), the "International Journal of Surgery" (since 2005), the “Journal of Pathology” (since 2006), and "Clinical and Experimental Immunology (since 2006).

Professional memberships include: The Transplantation Society, The International Xenotransplantation Association, The European Society of Organ Transplantation, The Dutch Society of Surgery and The Dutch Society of Transplantation.

He defended his PhD thesis entitled "Investigations relating to the induction of immunological tolerance through spleen transplantation in miniature swine" cum laude on October 11th 2006 at the Erasmus University Rotterdam (promotors: Prof. Dr J.N.M. IJzermans & Prof. Dr D.K.C. Cooper).

WEBSITE

http://www.dorgroot.com/medicalhome.htm [1]

INTERVIEWS AND MEDIA

1. Xenotransplantation: the end of organ transplantation waiting lists? (Article in Dutch) [2]

2. Exchange affairs (Fulbright): [3]

3. Interview in the Dutch newspaper "De Volkskrant" (January 2005) on Xenotransplantation [4]

4. Press Release PhD thesis defense in Medical News Today: [5]

DISSERTATION ON-LINE

Available in the near future...

PUBLICATIONS

K.E. Doucette, F.J.M.F. Dor, R.A. Wilkinson, S.I. Martin, G. Short, C.A. Huang, M. Freeman, D.K.C. Cooper, D.H. Sachs, J.A. Fishman. Gene expression of porcine lymphotrophic herpesvirus-1 (PLHV-1) in miniature swine with posttransplant lymphoproliferative disorder. Transplantation. In Press.

F.J.M.F. Dor, M.L. Ramirez, K. Parmar, E.L. Altman, C.A. Huang, J.D. Down, D.K.C. Cooper. Primitive hematopoietic cells reside in the spleen: studies in the pig, baboon, and human. Experimental Hematology 2006;34:1573–1582.

B.S. Wong, K. Yamada, M. Okumi, J. Weiner, P.E. O’Malley, Y-L. Tseng, F.J.M.F. Dor, D.K.C. Cooper, S.L. Saidman, A. Griesemer, D.H. Sachs. Allosensitization does not increase the risk of xenoreactivity to a1,3-galactosyltransferase gene-knockout (GalT-KO) miniature swine in patients on transplantation waiting lists. Transplantation 2006;82:314-319.

F.J.M.F. Dor, D.K.C. Cooper. Engraftment potential of adult spleen cells in vitro and in vivo. Transplant Immunology 2006;16:131.

F.J.M.F. Dor, D.K.C. Cooper. Immunological benefits of spleen transplantation in the absence of graft-versus-host disease. Annals of Surgery 2006;243;710-711.

Y-L. Tseng, K. Moran, F.J.M.F. Dor, T.M. Sanderson, W. Li, C.J. Lancos, H-J. Schuurman, D.H. Sachs, D.K.C. Cooper. Elicited antibodies in baboons exposed to tissues from a1,3- galactosyltransferase gene-knockout pigs. Transplantation 2006;81:1058-1063.

F.J.M.F. Dor, Y-L. Tseng, K. Kuwaki, B. Gollackner, M.L. Ramirez, D.D. Prabharasuth, R.A. Cina, C. Knosalla, M.G. Nuhn, S.L. Houser, C.A. Huang, D.S.C. Ko, D.K.C. Cooper. Immunological unresponsiveness in chimeric miniature swine following MHC-mismatched spleen transplantation. Transplantation 2005;80:1791-1804.

Y-L. Tseng, K. Kuwaki, F.J.M.F. Dor, A. Shimizu, S.L. Houser, Y. Hisashi, K. Yamada, S.C. Robson, M. Awwad, H-J. Schuurman, D.H. Sachs, D.K.C. Cooper. Alpha1,3-galactosyltransferase gene-knockout pig heart transplantation in baboons with survival approaching six months. Transplantation 2005;80:1493-1500.

M.L. Ramirez, I.M. McMorrow, T.M. Sanderson, C. J. Lancos, Y-L Tseng, D.K.C. Cooper, F.J.M.F. Dor. Lack of cardiac differentiation in c-kit-enriched porcine bone marrow and spleen hematopoietic cell cultures using 5-azacytidine. Cells Tissues Organs 2005;180:195-203.

K. Kuwaki, Y-L. Tseng, F.J.M.F. Dor, A. Shimizu, D.H. Sachs, D.K.C. Cooper. Localized myocardial infarction following pig-to-baboon heart transplantation. Xenotransplantation 2005; 12:489-491.

F.J.M.F. Dor, K. Kuwaki, Y-L. Tseng, A. Shimizu, S.L. Houser, M. Awwad, D.H. Sachs, H-J. Schuurman, J.N.M. IJzermans, D.K.C. Cooper. Transplantatie van alpha1,3-galactosyltransferase gen-knockout varkensharten in bavianen. Nederlands Tijdschrift voor Heelkunde 2005;14(3) :93.

F.J.M.F. Dor, F.J. Rouhani, D.K.C. Cooper. Re: Porcine RBCs Express a Polyagglutinable RBC Phenotype. Transfusion 2005;45:1036-1037.

F.J.M.F. Dor, K. Kuwaki, Y-L. Tseng, A. Shimizu, S.L. Houser, K. Yamada, R.J. Hawley, C. Patience, M. Awwad, J.A. Fishman, S.C. Robson, D.H. Sachs, H-J. Schuurman, D.K.C. Cooper. Potential of aspirin to inhibit thrombotic microangiopathy (TM) in a1,3-galactosyltransferase gene-knockout (GalT-KO) pig hearts after transplantation in baboons. Transplant Proc 2005;37(1):489-490.

F.J.M.F. Dor, B. Gollackner, K. Kuwaki, D.S.C. Ko, D.K.C. Cooper, S.L. Houser. Histopathology of spleen allograft rejection in miniature swine. International Journal of Experimental Pathology 2005;86:57-66.

K. Kuwaki, C. Knosalla, F.J.M.F. Dor, B. Gollackner, Y-L. Tseng, S. Houser, D.K.C. Cooper. Troponin T levels in baboons with pig heterotopic heart transplants. J Heart Lung Transplant 2005;24:92-94.

K. Kuwaki, Y-L. Tseng, F.J.M.F. Dor, A. Shimizu, S.L. Houser, T.M. Sanderson, C.J. Lancos, D.D. Prabharasuth, J. Cheng, K. Moran, Y. Hisashi, N.J. Mueller, K. Yamada, J.L. Greenstein, R.J. Hawley, C. Patience, M. Awwad, J.A. Fishman, S.C. Robson, H-J. Schuurman, D.H. Sachs, D.K.C. Cooper. Heart transplantation in baboons using a1,3-galactosyltransferase gene-knockout pigs as donors: initial experience. Nature Medicine 2005;11(1):29-31.

N.J. Mueller, K. Kuwaki, C. Knosalla, F.J.M.F. Dor, B. Gollackner, R.A. Wilkinson, J.S. Arn, D.K.C. Cooper, D.H. Sachs, J.A. Fishman. Early Weaning of Piglets Fails to Exclude Porcine Lymphotropic Herpesvirus. Xenotransplantation 2005;12:59-62.

N.J. Mueller, K. Kuwaki, F.J.M.F. Dor, C. Knosalla, B. Gollackner, R.A. Wilkinson, D.K.C. Cooper, D.H. Sachs, J.A. Fishman. Exclusion of Porcine Cytomegalovirus but not Porcine Lymphotropic Herpesvirus by Early Weaning of Piglets: Reduction of Consumptive Coagulopathy in Pig-to-Primate Xenotransplantation. Transplantation 2004;78:1449-1454.

F.J.M.F. Dor, M.L. Ramirez, E.L. Altman, P. Lee, C.A. Huang, J.D. Down, D.K.C. Cooper. The spleen as a source of hematopoietic stem cells: potential for tolerance induction. Transplantation 2004;78 Suppl 1:590.

D K.C. Cooper, K. Kuwaki, Y-L. Tseng, F.J.M.F. Dor, A. Shimizu, S.L. Houser, K. Yamada, R.J. Hawley, C. Patience, M. Awwad, J.A. Fishman, S.C. Robson, D.H. Sachs, H.J. Schuurman. The potential of aspirin to inhibit thrombotic microangiopathy in GalT-KO pig hearts after transplantation into baboons. Transplantation 2004;78 Suppl 1: 186-187.

S.L. Houser, K. Kuwaki, C. Knosalla, F.J.M.F. Dor, B. Gollackner, J. Cheng, A. Shimizu, H-J. Schuurman, D.K.C. Cooper. Thrombotic microangiopathy and graft arteriopathy in pig hearts following transplantation into baboons. Xenotransplantation 2004;11:416-425.

F.J.M.F. Dor, K.E. Doucette, N.J. Mueller, R.A. Wilkinson, J.A. Bajwa, I.M. McMorrow, Y-L. Tseng, K. Kuwaki, S.L. Houser, J.A. Fishman, D.K.C. Cooper, C.A. Huang. Post-transplant lymphoproliferative disease after allogeneic transplantation of the spleen in miniature swine. Transplantation 2004;78:286-291.

F.J.M.F. Dor, Y-L. Tseng, J. Cheng, K. Moran, T.M. Sanderson, C.J. Lancos, A. Shimizu, K. Yamada, M. Awwad, D.H. Sachs, R.J. Hawley, H-J. Schuurman, D.K.C. Cooper. a1,3-galactosyltransferase gene-knockout miniature swine produce natural cytotoxic anti-Gal antibodies. Transplantation 2004;78:15-20.

F.J. Rouhani*, F.J.M.F. Dor*, D.K.C. Cooper. Investigation of erythrocytes from alpha1,3galactosyltransferase gene-knockout pigs for human blood transfusion. Transfusion 2004;44:1004-1012.

Y-L. Tseng, F.J.M.F. Dor, K. Kuwaki, D. Ryan, J. Wood, M. Denaro, M. Giovino, K. Yamada, R. Hawley, C. Patience, H-J. Schuurman, D.H. Sachs, M. Awwad, D.K.C. Cooper. Initial results of bone marrow transplantation from a1,3-galactosyltransferase gene-knockout pigs in baboons. Xenotransplantation 2004;11:361-370.

F.J.M.F. Dor, D.K.C. Cooper. Letter to the Editors. Xenotransplantation 2004;11:382.

Y-L. Tseng, F.J.M.F. Dor, K. Kuwaki, D. Prabharasuth, A. Alt, D. Ryan, M. Denaro, M. Giovino, J. Wood, K. Yamada, R. Hawley, M. Awwad, C. Patience, H-J. Schuurman, D.H. Sachs, D.K.C. Cooper. Transplantation of a1,3-galactosyltransferase gene-knockout pig bone marrow in baboons. Am J Transplant 2004;4 Suppl 8:243.

Y-L. Tseng, K. Kuwaki, F.J.M.F. Dor, A. Shimizu, S.L Houser, T.M. Sanderson, C.J. Lancos, D. Prabharasuth, K. Yamada, R.J. Hawley, C. Patience, M. Awwad, J.A. Fishman, S.C. Robson, D.H. Sachs, H-J Schuurman, D.K.C. Cooper. Transplantation of hearts from a1,3-galactosyltransferase gene-knockout pigs into baboons. Am J Transplant 2004;4 Suppl 8:450-451.

S.L. Houser, A. Shimizu, K. Kuwaki, F.J.M.F. Dor, Y-L Tseng, C. Knosalla, J. Cheng, H-J Schuurman, D.H. Sachs, D.K.C. Cooper. Thrombotic microangiopathy in hDAF and GalT-KO pig hearts following transplantation into baboons. Am J Transplant 2004;4 Suppl 8:451.

F.J.M.F. Dor, K.E. Doucette, N.J. Mueller, R.A. Wilkinson, J.A. Bajwa, I.M. McMorrow, Y-L. Tseng, K. Kuwaki, S.L. Houser, D.H. Sachs, J.A. Fishman, C.A. Huang, D.K.C. Cooper. Post-transplant lymphoproliferative disease after allogeneic spleen transplantation in miniature swine. Am J Transplant 2004;4 Suppl 8:462.

F.J.M.F. Dor, Y-L. Tseng, J. Cheng, K. Moran, T.M. Sanderson, C.J. Lancos, A. Shimizu, M. Awwad, D.H. Sachs, R.J. Hawley, H-J. Schuurman, D.K.C. Cooper. Pigs lacking the a1,3-galactosyltransferase gene develop anti-Gal antibodies that are cytotoxic to wild-type (Gal+/+) MHC-matched pig cells: a potential model to study accommodation. Am J Transplant 2004;4 Suppl 8:599.

N.J. Mueller, C. Livingston, C. Knosalla, R. Barth, S. Yamamoto, B. Gollackner, F.J.M.F. Dor, L. Buhler, D.H. Sachs, K. Yamada, D.K.C. Cooper, J.A. Fishman. Activation of porcine cytomegalovirus but not porcine lymphotropic herpesvirus in pig-to-baboon xenotransplantation. Journal of Infectious Diseases 2004;189:1628-1634.

F.J.M.F. Dor, Y-L. Tseng, K. Kuwaki, D.S.C. Ko, D.K.C. Cooper. Pig spleen transplantation induces transient hematopoietic cell chimerism in baboons. Xenotransplantation 2004;11:295-297.

F.J.M.F. Dor, F.J. Rouhani, D.K.C. Cooper. Transfusion of pig red blood cells into baboons. Xenotransplantation 2004;11:298-300.

C. Knosalla, K. Kuwaki, F.J.M.F. Dor, B. Gollackner, Y-L. Tseng, S. Houser, I. Schmitt, K. Moran, D.H. Sachs, R. Duthaler, A. Katopodis, H-J. Schuurman, M. Awwad, R. Hetzer, D.K.C. Cooper. Recent advances in cardiac xenotransplantation using an human anti-human CD154 monoclonal antibody based protocol. The Thoracic and Cardiovascular Surgeon 2004;52(S1):16.

K. Kuwaki, C. Knosalla, F.J.M.F. Dor, B. Gollackner , Y-L. Tseng, S. Houser, N. Mueller, Prabharasuth D, A. Alt, K. Moran, J. Cheng, A. Behdad, D.H. Sachs, J.A. Fishman, H-J. Schuurman, M. Awwad, D.K.C. Cooper. Suppression of natural and elicited antibodies in pig-to-baboon heart transplantation using a human anti-CD154 monoclonal antibody-based regimen. Am J Transplant 2004;4:363-372.

J.M. Eckermann, L.H. Buhler, A. Zhu, F.J.M.F. Dor, M. Awwad, D.K.C. Cooper. Initial investigation of the potential of modified porcine erythrocytes for transfusion in primates. Xenotransplantation 2004;11:18-26.

R.M. Baertschiger, F.J.M.F. Dor, D. Prabharasuth, K. Kuwaki, D.K.C. Cooper. Absence of humoral and cellular alloreactivity in baboons sensitized to pig antigens. Xenotransplantation 2004;11:27-32.

F.J.M.F. Dor, J. Cheng, A. Alt, D.K.C. Cooper, H-J. Schuurman. Gal a1,3Gal expression on porcine pancreatic islets, testis, spleen and thymus. Xenotransplantation 2004;11:101-106.

F.J.M.F. Dor, B. Gollackner, D.K.C. Cooper. Can spleen transplantation induce tolerance? A review of the literature. Transpl Int. 2003;16:451-460[Epub Jul 8].

B.Gollackner*, N.J. Mueller*, S.L. Houser, I. Qawi, D. Soizic, C. Knosalla, L. Buhler, F.J.M.F. Dor, M. Awwad, D.H. Sachs, D.K.C. Cooper, S.C. Robson, J.A. Fishman. Porcine cytomegalovirus and coagulopathy in pig-to-primate xenotransplantation. Transplantation 2003;75:1841-1847.

B. Gollackner*, F.J.M.F. Dor*, C. Knosalla, L. Buhler, M. Duggan, C.A. Huang, S.L. Houser, D.H. Sachs, T. Kawai, D.S.C. Ko, D.K.C. Cooper. Spleen transplantation in miniature swine: surgical technique and results in MHC-matched donor and recipient pairs. Transplantation 2003;75:1799-1806.

F.J.M.F. Dor, B. Gollackner, K. Kuwaki, D. Prabharasuth, A. Alt, S.L. Houser, C. Knosalla, M. Duggan, T. Kawai, D.S.C. Ko, C.A.Huang, C. LeGuern, D.H. Sachs, D.K.C. Cooper. Donor-specific unresponsiveness and mixed hematopoietic chimerism following allogeneic spleen transplantation in miniature swine. Am J Transplant 2003;3 Suppl 5:263.

N.J. Mueller, C. Knosalla, K. Kuwaki, F.J.M.F. Dor, B. Gollackner, D.H. Sachs, D.K.C. Cooper, J.A. Fishman. Prevention of porcine (PCMV) and baboon (BCMV) cytomegalovirus infections in pig-to-primate xenotransplantation: possible role in consumptive coagulopathy. Am J Transplant 2003;3 Suppl 5:412.

K. Kuwaki, C. Knosalla, F.J.M.F. Dor, B. Gollackner, S. Houser, D. Prabharasuth, A. Alt, D.H. Sachs, H-J. Schuurman, M. Awwad, D.K.C. Cooper. Suppression of natural and elicited antibodies in pig-to-baboon heart transplantation. Am J Transplant 2003;3 Suppl 5:413.

K. Kuwaki, F.J.M.F Dor, D.K.C. Cooper. Primates as models for xenotransplantation. Current Opinion in Organ Transplantation 2003;8(1):89-93.

C. Knosalla, K. Teranishi, B. Gollackner, F.J.M.F. Dor, D.K.C. Cooper. Neurotoxicity of leflunomide in baboons. Xenotransplantation 2003;10(2):187-188.

S.L. Houser*, F.J.M.F. Dor*, B. Gollackner, D.K.C. Cooper. Histopathological characterization of splenic allograft rejection in miniature swine. Lab Invest 2003;83:296A

C. Knosalla, B.Gollackner, F.J.M.F. Dor, D.K.C. Cooper. Therapeutic interventions in xenotransplantation. Current Drug Targets-Cadiovas.& Haemat. Dis. 2002;2:105-119.

B.Gollackner*, F.J.M.F. Dor*, C. Knosalla, S. Houser, M. Duggan, D.H. Sachs, D.S.C. Ko, D.K.C. Cooper. Initial studies of spleen transplantation in miniature swine. Transplantation 2002;Aug 27;74(4):293-294.

F.J.M.F. Dor, F.B.S. Oei, L.M.B. Vaessen, R.L. Marquet, A.J.J.C. Bogers, W. Weimar. Frequencies of donor reactive Helper T Lymphocytes correlate with rejection of fresh aortic valve allografts in rats. Journal of Heart Valve Disease 2002;11(3):326-335.

F.B.S. Oei, F.J.M.F. Dor, A.P.A. Stegmann, M.J.P. Welters, L.M.B. Vaessen, R.L. Marquet, A.J.J.C. Bogers, W. Weimar. Helper T cell frequencies after implantation of aortic valve allografts in rats. Transplantation Proc 2001 Feb-Mar;33(1-2):640-1.

F.J.M.F. Dor, F.B.S. Oei, M.J.P. Welters, L.M.B. Vaessen, R.L. Marquet, A.J.J.C. Bogers, W. Weimar. Cellulaire afstoting van allogene hartkleppen in de rat. Nederlands Tijdschrift voor Geneeskunde-studenteneditie 2000; 3(4): 61-65.

F.J.M.F. Dor, M.I. Cleton, G. de Jong, H.G. van Eijk. Clinical chemistry in the medical curriculum: from practical to research. Biochemical Education 1998; 26: 317-319.

F.J.M.F. Dor, G. de Jong, H.G. van Eijk. Klinische chemie in de medische opleiding: van practicum tot onderzoek. Nederlands Tijdschrift voor Klinische Chemie 1998; 23(1): 24-26.