There are three important routes of glucose conversion to pyruvate such as glycolysis or Embden-Myerhof pathway (BMP) pathway, pentose phosphate pathway, and Entner-Doudroff pathway. The pentose phosphate pathway actually exist in the cytosol and can be break up into two phases: Oxidative phase: The oxidative portion of HMP shunt composes of 3 chemical reactions that lead to the production of Ribulose-5-Phosphate, Carbon dioxide and 2 additional molecules of NADPH, for each molecule of Glucose-6-Phosphate would get oxidized. Video lesson on the pentose phosphate pathway (hexose monophosphate shunt), the purpose of the pathway and the importance in human health. Oxidative phase of pentose phosphate pathway. Learn vocabulary, terms, and more with flashcards, games, and other study tools. The oxidative pentose phosphate pathway converts between 15 and 30% of hexose phosphate to glyceraldehyde-3-phosphate and CO 2 in pea and spinach chloroplasts. sugars) via the Pentose Phosphate Pathway. While this pathway has been investigated in the intact brain and in … Ribose 5-phosphate. Oxidative phase of the pentose phosphate pathway consists of three reactions that lead to the formation of three products for each molecule of glucose 6 phosphate oxidation. Pentose phosphate reactions (Interconversion of Pentoses) and Conversion of pentose phosphates to hexose phosphates. 1. Ribose-5-phosphate (R5P) is produced by the last step of the oxidative phase of the Pentose Phosphate pathway. Fructose‐6‐phosphate, the hexose, is a glycolytic intermediate and can enter that pathway at this stage. (1) Important for biosynthetic pathways using NADPH, and (2) a high cytosolic reducing potential from NADPH is sometimes required to advert oxidative damage by radicals, e.g., O 2-and H—O Start studying Pentose Phosphate Pathway. Is the Pentose Phosphate Pathway just about making ribose sugars from glucose? R5P is important for the generation of nucleotides, which are required for DNA and RNA synthesis. Glycolysis is the most important type of mechanism by which organisms obtain energy from organic compounds in absence of molecular oxygen. Hey guys! R5P is … Pentose Phosphate Pathway: Definition, Importance, Steps. Pentose Phosphate Pathway • Like glycolysis it occurs in cytosol • Oxidation is achieved by dehydrogenation using NADP+, not NAD+ • Its carried out in 2 step: – Irreversible oxidative phase: 3 molecules of glucose-6-phosphate give rise to 3 … Glucose-6-phosphate dehydrogenase and a lactonase catalyze the first committed step of the oxidative pentose phosphate pathway which is a strategic control point. The brain is highly susceptible to oxidative injury, and the pentose phosphate pathway (PPP) has been shown to be affected by pathological conditions, such as Alzheimer's disease and traumatic brain injury. Biochemistry. 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